DESQUAMATIVEINTERSTITIAL PNEUMONITIS AND LEUKEMIA 321 Desquamative Interstitial Pneumonitis Associated with Monomyelocytic Leukemia*
نویسنده
چکیده
D esquamative interstitial pneumonitis ( DIP) is an inflammatory process in the lung characterized histologically by massive accumulation of intra-alveolar mononuclear cells, predominantly alveolar macrophages ( PAMs ) , without necrosis, fibrin exudates, hyaline membranes, or extensive fibrosis.1’2 Whether DIP is a distinct clinicopathologic entity or is merely part of a spectrum of fibrosing alveolitis remains controversial;3 however, patients with DIP tend to respond better to glucocorticoids, progress to “honeycomb lung” less frequently, and survive longer than patients with usual interstitial pneumonitis ( UIP ).4 The etiology of DIP is unknown, but more than one cause is likely since a variety of associated diseases and conditions have been noted in scattered cases.512 This report describes two patients with a previously unknown association-DIP and monomyelocytic leukemia. The findings in these cases provide additional evidence that alveolar macrophages and their precursors are still capable of responding to inflammatory stimuli even in the presence of hematologic malignancy.
منابع مشابه
Lymphocytic interstitial pneumonitis (LIP)-the liver and the lung.
Chronic liver disease may involve the lung through abnormal communications between the portal and pulmonary veins or by changes in the lungs caused by similar biochemical abnormalities to those in liver parenchyma. Lymphocytic interstitial pneumonitis(LIP) is more common in women and is associated with autoimmune diseases. Chest x-ray findings include reticular or reticulonodular opacities whil...
متن کاملIdelalisib-induced pneumonitis.
To cite: Gupta A, Li HC. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/ bcr-2016-216343 DESCRIPTION Awoman in her 40s with relapsed follicular lymphoma presented with a few days history of shortness of breath and cough producing yellow sputum. There were no reported toxic exposures or contacts with sick people. Medications included idelalisib initiated 5 months ago ...
متن کاملChlorambucil-Induced Acute Interstitial Pneumonitis
Chlorambucil is an alkylating agent commonly used in treatment of chronic lymphocytic leukemia (CLL). We report a case of interstitial pneumonitis developing in an 83-year-old man 1.5 months after completing a six-month course of chlorambucil for CLL. The interstitial pneumonitis responded to therapy with prednisone. We performed a systematic review of literature and identified 13 other case re...
متن کاملSuccessful Rechallenge with Imatinib in a Patient with Chronic Myeloid Leukemia Who Previously Experienced Imatinib Mesylate Induced Pneumonitis
Imatinib mesylate is a targeted therapy that acts by inhibiting tyrosine kinase of the bcr-abl fusion oncoprotein, which is specific to chronic myeloid leukemia (CML), and the c-transmembrane receptor, which is specific to gastrointestinal stromal tumors. Interstitial pneumonitis is a rare adverse event of imatinib therapy. It is clinically difficult to distinguish from infectious pneumonia, wh...
متن کاملLymphocytic interstitial pneumonitis in HIV infected adults.
OBJECTIVES To describe current knowledge on the aetiology, pathology, presentation, diagnosis, and treatment of lymphocytic interstitial pneumonitis in HIV infected adults. METHODS A Medline search was performed using the key words "HIV," "pneumonitis," and "lymphocytes." A further search was performed with the MESH heading "interstitial lung disorders." Related articles were also searched us...
متن کامل